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        Research

        Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

        Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. ...

        Research

        Talking skin: Attitudes and practices around skin infections, treatment options, and their clinical management in a remote region in Western Australia

        Documenting carer, service provider and healthcare practitioner perspectives on skin infections provides more understanding of the context of treatment decisions ...

        Research

        Children with secondary care episodes for otitis media have poor literacy and numeracy outcomes: A data linkage study

        We examined the association between otitis media and educational attainment in a retrospective population cohort of Western Australian children who participated in the Grade 3 National Assessment Program—Literacy and Numeracy in 2012. ...

        Research

        Meningococcal serotype W septic arthritis: Case series in children

        The epidemiology of invasive meningococcal disease has changed over the last decade and there has been an increase in cases caused by serogroup W135, particularly in Indigenous children. Extra‐meningeal and atypical presentations are associated with serogroup W and may delay diagnosis and therefore appropriate treatment. Public and clinician awareness are essential in facilitating effective new vaccine schedule implementation. ...

        Research

        Determining the off-target effects of infant vaccines on respiratory infection outcomes in Western Australian children

        Christopher Hannah Lea-Ann Blyth Moore Kirkham CC HC LK MBBS (Hons) DCH FRACP FRCPA PhD OAM BSc (Hons) GradDipClinEpi PhD PhD Director, Wesfarmers ...

        Research

        How Accurate Are International Classification of Diseases-10 Diagnosis Codes in Detecting Influenza and Pertussis Hospitalizations in Children?

        Influenza diagnosis codes had high specificity (98.6%) and modest positive predictive value (PPV; 84.1%) and sensitivity (86.1%) for a laboratory-confirmed... ...

        Research

        Influenza vaccination in Western Australian children: Exploring the health benefits and cost savings of increased vaccine coverage in children

        To assess potential benefits and direct healthcare cost savings with expansion of an existing childhood influenza immunisation program, we developed a dynamic transmission model for the state of Western Australia, evaluating increasing coverage in children < 5 years and routinely immunising school-aged children. ...

        Research

        Roadmap to incorporating group A Streptococcus molecular point-of-care testing for remote Australia: a key activity to eliminate rheumatic heart disease

        Jonathan Asha Dylan Rosemary Janessa Carapetis AM Bowen Barth Wyber Pickering JR AC DB R Dr AM MBBS FRACP FAFPHM PhD FAHMS BA MBBS DCH FRACP PhD ...

        Research

        The fall and rise of Group A Streptococcus diseases

        We overview the changing epidemiology of Group A Streptococcus infections and the genetic alterations that accompany the emergence of Group A Streptococcus strains ...

        Research

        Dedicated paediatric Outpatient Parenteral Antimicrobial Therapy medical support: a pre-post observational study

        We examined the impact of introducing a dedicated team to OPAT, to define the role of increased medical oversight in improving patient outcomes in this cohort. ...

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