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        361-370 of 654 results for 'Gene'

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        Tumour treatment needs targeted approach

        Advances in gene and molecular technology finally explain why brain tumour cells that look the same, behave and respond differently to treatment. ...

        Research

        A systematic review of prevention interventions to reduce prenatal alcohol exposure and fetal alcohol spectrum disorder in Indigenous communities

        Liz Martyn Milne Symons E MS MPH PhD B.A. (Hons) PhD. Honorary Emeritus Fellow Honorary Research Associate 08 6319 1672 martyn.symons@ ...

        Research

        In silico evolution of nucleic acid-binding proteins from a nonfunctional scaffold

        Directed evolution emulates the process of natural selection to produce proteins with improved or altered functions. These approaches have proven to be very powerful but are technically challenging and particularly time and resource intensive. To bypass these limitations, we constructed a system to perform the entire process of directed evolution in silico. ...

        Research

        Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency

        We aimed to investigate the molecular basis underlying a novel phenotype including hypopituitarism associated with primary ovarian insufficiency. ...

        Research

        Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

        A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator PrfA controls expression of key virulence factors that enable exploitation of this intracellular niche. ...

        Research

        Microbiome and Functional Analysis of a Traditional Food Process: Isolation of a Novel Species (Vibrio hibernica) With Industrial Potential

        Vibrio hibernica is capable of metabolizing a unique carbohydrate profile at low temperatures ...

        Research

        Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia

        These findings add additional evidence to the hypothesis that regular contact with animals in early childhood is inversely associated with childhood acute lymphoblastic leukemia ...

        Research

        Childhood brain tumours: Associations with parental occupational exposure to solvents

        Paternal exposure to solvents in the year before conception was associated with an increased CBT risk. This increased risk appeared to be mainly attributable... ...

        Research

        Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling

        Progesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, rapid acute induction of PGR is the key determinant of ovulation through transcriptional control of a unique set of genes that culminates in follicle rupture. However, the molecular mechanisms for this specialized PGR function in ovulation is poorly understood. ...

        Research

        Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities

        Reading Disability is often characterized by difficulties in the phonology of the language. While the molecular mechanisms underlying it are largely undetermined, loci are being revealed by genome-wide association studies. ...

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