Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled ETO2 depletion models. We demonstrate that beyond its well-established repressive activity, ETO2 directly activates transcription of MYB, among other genes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

The presence of membrane-bound organelles with specific functions is one of the main hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that govern their function and interorganelle communication. Discoveries in cell biology using imaging and omic technologies have revealed the mechanisms that drive membrane remodeling, organelle contact sites, and metabolite exchange. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024

To characterise the socio-demographic characteristics, aged and health care needs, and aged care services used by older Aboriginal and Torres Strait Islander people assessed for aged care service eligibility. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024

Early childhood is foundational for optimal and inclusive lifelong learning, health and well-being. Young children with disabilities face substantial risks of sub-optimal early childhood development, requiring targeted support to ensure equitable access to lifelong learning opportunities, especially in low- and middle-income countries.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

Difficulties in executive functioning (EF) can result in impulsivity, forgetfulness, and inattention. Children living in remote/regional communities are particularly at risk of impairment in these cognitive skills due to reduced educational engagement and poorer access to interventions. This vulnerability has been exacerbated by the COVID-19 pandemic and strategies are needed to mitigate long-term negative impacts on EF. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

This study uses data from a large international database, InterRett, to examine genotype-phenotype relationships and compares these with previous findings in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2008
• March 2008

Siblings of children with disabilities: challenges and opportunities ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• January 2009

In 2002, the Founding Director of the Telethon Institute for Child Health Research, Professor Fiona Stanley, approached Rio Tinto Ltd about the possibility... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2008
• August 2008

The ultimate goal of the Alcohol and Pregnancy and FASD Research Team is to make FASD history in Australia. ...

• 1. Telethon Kids Institute
• Our research
• Brain and Behaviour
• Development and Disability

The Health of Aboriginal Children and Young People ...

• 1. Telethon Kids Institute
• Our research
• Indigenous Health
• WA Aboriginal Child Health Survey (WAACHS)