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        Research

        Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry

        Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells. ...

        Research

        Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea

        Vaccination trials in high endemicity areas are needed to provide evidence and guidance on idea strategies to protect children in these areas against infections ...

        Research

        Taking a prebiotic approach to early immunomodulation for allergy prevention

        In this review we examine maternal and infant dietary sources of prebiotics with a particular focus on non-digestible oligosaccharides, which undergo SCFA. ...

        Research

        Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age: a double-blind, randomised controlled clinical trial

        This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years) ...

        Research

        Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observed

        We aim to provide our view of where we are and where we need to go as a community of clinicians and researchers who tackle the public health problem of asthma. ...

        Research

        The Promise of Electroencephalography for Advancing Diagnosis and Treatment in Neurodevelopmental Disorders

        NDD's such as ASD, ADHD and ID, commonly emerge during early development and impacts function across cognitive, social-emotional, communication and sensorimotor ...

        Research

        Blueprint for the House Dust Mite

        The completeness of the coverage of a genome assembly is a critical starting point for all genomic projects so considerable attention is given to the sequencing metrics, which showed high indicators of success. ...

        Research

        Epidemiology of the cerebral palsies

        Epidemiology of CP aims to describe the frequency of the condition in a population and to monitor its changes over time ...

        Research

        Mental health problems among 4–17-year-olds with hearing problems: results from a nationally representative study

        Clinicians caring for children and young people with hearing problems should be alert for heightened risk of specific mental health problems based on age and the nature of hearing problems. ...

        Research

        Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever

        A sample target product profile for reformulated benzathine penicillin G is presented ...

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