The human placenta is a rapidly developing transient organ that is key to pregnancy success. Early development of the conceptus occurs in a low oxygen environment before oxygenated maternal blood begins to flow into the placenta at ~10–12 weeks’ gestation. This process is likely to substantially affect overall placental gene expression. Transcript variability underlying gene expression has yet to be profiled. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Biological changes associated with T-ALL relapse and resistance are stochastic and highly individual ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• August 2016

Connective tissue growth factor (CTGF/CCN2) has been shown previously to be aberrantly expressed in a high proportion of paediatric precursor B cell acute... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• May 2015

Drug-resistant forms of acute lymphoblastic leukaemia (ALL) are a leading cause of death from disease in children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4+ T cell responses and their regulation by major histocompatibility complex class II (MHC II) in the skin. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and establishing leukemia-supportive interactions with stromal and immune cells. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

We demonstrated the efficacy of FPPa-OmoMYC in inhibiting breast cancer growth when injected orthotopically in TNBC allografts ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

One of the great success stories of modern medicine is undoubtedly the remarkable improvement in outcome for childhood cancer, achieved through the work of... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015