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        Research

        Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection

        The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood. ...

        Research

        Variants associated with HHIP expression have sexdifferential effects on lung function

        Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. ...

        Research

        Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae

        The aim of this study was to identify features of innate, cell-mediated and humoral immunity that may increase susceptibility to respiratory infections in... ...

        Research

        An exposome perspective: Early-life events and immune development in a changing world

        Here we review the historical origins of exposome research and define a new concept, the metaexposome ...

        Research

        Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C

        Medically attended RV-C-induced wheeze is characterised by a Th2 inflammatory pattern, independent of viral load ...

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        Professor Graham Hall

        Honorary Research Associate ...

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        Research

        CD4 allergen tetramers

        The introduction of class II tetramers for identifying antigen-binding CD41 cells has lagged behind the use of class I tetramers because of difficulties... ...

        Research

        Effect of the increase in "alcopops" tax on alcohol-related harms in young people: a controlled interrupted time series

        The objective of this study was to measure alcohol-related harms to the health of young people presenting to emergency... ...

        Research

        Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny

        We sought to explore whether allergic children show differences in microbial Toll-like receptor (TLR)-mediated responses over their first 5 years of life. ...

        The PrEggNut Study

        Does the amount of eggs and peanuts a mother eats during pregnancy and breastfeeding have an influence on whether her baby will develop an egg or peanut food allergy? ...

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