Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Interfant-06 protocol, which compared lymphoid-style consolidation (protocol IB) versus myeloid-style consolidation (araC, daunorubicin, etoposide/mitoxantrone, araC, etoposide). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Infant MLL-AF4-driven acute lymphoblastic leukemia (ALL) is a devastating disease with dismal prognosis. A lack of understanding of the unique biology of this disease, particularly its prenatal origin, has hindered improvement of survival. We perform multiple RNA sequencing experiments on fetal, neonatal, and adult hematopoietic stem and progenitor cells from human and mouse. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Adolescents reporting any sychotic experiences in the past 12 months reported increased likelihood of non-accidental self-injury in the same time period ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Steve Zubrick SR FASSA, FAAMHS, MSc AM PhD Honorary Emeritus Research Fellow 08 6319 1409 Stephen.zubrick@telethonkids.org.au Honorary Emeritus ...

• 1. Telethon Kids Institute
• Our research
• Brain and Behaviour
• Population Health Program
• Human Development and Community Wellbeing

We review findings from our previous studies which show the application of a person-based resilience framework of analysis in the context of WA aboriginal youth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• April 2018

To identify factors associated with generalized and stranger-specific PF about CIM, a critical aspect of physical activity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

This article describes the survey, the response rates achieved and the representativeness of the sample for the Young Minds Matter survey ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

Our results demonstrate a range of multiple risk profiles in a population-representative sample of Australian children and highlight the mix of risk factors faced by children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

The typical number of visits to health professionals by children with mental disorders during a 12-month period is relatively small ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

The objective of this study was to examine the influence of aggressive behaviour scores on cardiovascular disease (CVD) risk factors throughout childhood. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• August 2012