RNA-sequencing (RNA-seq) efforts in acute lymphoblastic leukaemia have identified numerous prognostically significant genomic alterations which can guide diagnostic risk stratification and treatment choices when detected early. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

Unlike adults, malignant melanoma in children and adolescents is rare. In adult melanoma, significant progress in understanding tumor biology and new treatments, including targeted therapies and immunotherapy have markedly improved overall survival. In sharp contrast, there is a paucity of data on the biology and clinical behavior of pediatric melanoma. We report a national case series of all pediatric and adolescent malignant melanoma presenting to ANZCHOG Childhood Cancer Centers in Australia and New Zealand. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4+ T cell responses and their regulation by major histocompatibility complex class II (MHC II) in the skin. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

Advancements in genomic profiling led to the discovery of four major molecular subgroups in medulloblastoma (MB), which have now been incorporated into the World Health Organization classification of central nervous system tumors. The current study aimed to determine the prognostic significance of the MB molecular subgroups among children in Malaysia.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

We identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016