Antimicrobial resistance is a current global health crisis, and the increasing emergence of multidrug resistant infections has led to the resurgent interest in bacteriophages as an alternative treatment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

We aimed to systematically review and assess the performance of all published models that predicted development of COPD ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

Alexander Anthony Larcombe Kicic A A BScEnv (Hons) PhD BSc (Hons) PhD Team Leader, Respiratory Environmental Health Rothwell Family Fellow; Head, ...

• 1. Telethon Kids Institute
• Projects

The authors assessed the impact of including preschool‐aged children with a history of preterm birth, early life wheeze, asthma diagnoses and/or recent respiratory symptoms in healthy reference ranges for respiratory impedance using the forced oscillation technique (FOT). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• April 2018

COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• June 2012

Long-term survival after lung transplantation is hindered by the development of bronchiolitis obliterans syndrome (BOS). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

Although formaldehyde concentrations were very low, this finding is consistent with other studies of formaldehyde and poor birth outcomes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

No evidence to demonstrate relationships with symptoms and viruses, prolonged symptoms, prolonged shedding or patterns of virus infections in CF ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

When performing computerized tomography chest imaging in children, obtaining high quality, motion-free images is important in the accurate diagnosis of underlying pathology. General anesthesia is associated with the development of atelectasis, which can impair accurate diagnosis by obscuring or altering the appearance of the lung parenchyma or airways. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• April 2022