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        Research

        A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease

        Few children and adolescents receiving BPG as secondary prophylaxis will achieve concentrations >0.02 mg/L for the majority of the time between injections ...

        Research

        The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

        Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection ...

        Research

        Role of pre-existing adversity and child maltreatment on mental health outcomes for children involved in child protection: population-based data linkage study

        Young people who have been involved in the child protection system are at increased risk for mental health events and diagnoses ...

        Research

        Has a national policy guideline influenced the practice of raising the topic of alcohol and breastfeeding by maternal healthcare practitioners?

        Having a national policy guideline for safe alcohol consumption during lactation has not promoted awareness of this topic among maternal health practitioners ...

        Research

        Mapping the global endemicity and clinical burden of Plasmodium vivax, 2000-17: a spatial and temporal modelling study

        Our study highlights important spatial and temporal patterns in the clinical burden and prevalence of P vivax ...

        Research

        Implementing and Evaluating Interventions to Improve School Readiness and Early Literacy

        The implementation of the Pacific early age readiness and learning program has generated significant data, evidence, operational experience, and knowledge ...

        Research

        HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

        HLA-A*32:01 is strongly associated with vancomycin-induced DRESS in a population of predominantly European ancestry ...

        Research

        Risk factors for multidrug-resistant tuberculosis in northwest Ethiopia: A case–control study

        The aim of this study was to describe the characteristics of patients with multidrug-resistant tuberculosis and to investigate risk factors ...

        Research

        Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective Biocatalyst

        Evaluation of an esterase annotated as 26D isolated from a marine metagenomic library is described ...

        Research

        Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

        IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition ...

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