Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warrant the urgent development of more effective and cancer-selective therapeutics. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Functional role of CTGF in altering disease progression in a lymphoid malignancy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• September 2016

One of the great success stories of modern medicine is undoubtedly the remarkable improvement in outcome for childhood cancer, achieved through the work of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• April 2014

The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014

Investigation of this rare mixed lineage leukemia cytogenetic abnormality aims to provide further evidence of the genetic changes that underpin this leukemia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

The cure rate for pediatric patients with B precursor acute lymphoblastic leukemia (pre-B ALL) is steadily improving, however relapses do occur despite... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• September 2011