Current approaches to staging chronic liver diseases have limited utility for predicting liver cancer risk. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using two distinct mouse models. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

Effective antitumor CD8 T cell responses may be activated by directly targeting the innate immune system within tumors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2008
• February 2008

Senior Research Officer ...

• 1. Telethon Kids Institute
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• Our people
• Staff Profiles - K

Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• August 2009

We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

Despite decades of research, the mechanisms of ventilator-induced lung injury are poorly understood... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in hepatocytes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

Intrauterine growth restriction (IUGR) is associated with asthma. Murine models of IUGR have altered airway responsiveness in the absence of any inflammatory exposure. Given that a primary feature of asthma is airway inflammation, IUGR-affected individuals may develop more substantial respiratory impairment if subsequently exposed to an allergen. This study used a maternal hypoxia-induced mouse model of IUGR to determine the combined effects of IUGR and allergy on airway responsiveness. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021