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        31-40 of 73 results for 'raelene'

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        Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumors

        Nick Raelene Gottardo Endersby NG R MBChB FRACP PhD BSc (Hons) PhD Co-Head, Brain Tumour Research Brainchild Fellow; Co-Head, Brain Tumour Research ...

        Research

        BRAF-mediated brain tumors in adults and children: A review and the Australian and New Zealand experience

        The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most commonly mutated pathways in human cancers. In particular, BRAF alterations result in constitutive activation of the rapidly accelerating fibrosarcoma-extracellular signal-regulated kinase-MAPK significant pathway, leading to cellular proliferation, survival, and dedifferentiation. ...

        Research

        Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma

        Medulloblastoma is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects. ...

        Research

        The case for DNA methylation based molecular profiling to improve diagnostic accuracy for central nervous system embryonal tumors (not otherwise specified) in adults

        We report the case of a 45-year-old woman who was diagnosed with a NOS based on immunohistochemical analysis of the patient's tumor at diagnosis. ...

        Research

        In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma

        Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients. ...

        Research

        Long-term outcomes of symptomatic optic pathway glioma: 32-year experience at a single Western Australian tertiary pediatric oncology center

        Optic pathway gliomas (OPGs) are associated with significant risk of visual and endocrine morbidity, but data on long-term outcomes in symptomatic patients is sparse. This study reviews the clinical course, disease progression, survival outcomes and long-term sequelae in pediatric patients with symptomatic OPGs in our institution over three decades. ...

        Research

        Developing and characterising juvenile models of aggressive paediatric brain cancers for the evaluation of novel immunotherapies.

        Raelene Nick Jessica Annabel Meegan Jacqueline Endersby Golding Buck Short Howlett Whitehouse R NG JB AS MH JW BSc (Hons) PhD BSc DPhil DPhil BMedRes ...

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        Dr Meegan Howlett

        Senior Postdoctoral Researcher and Research Project Manager ...

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        Trial aims to improve survival rates for kids with brain cancer

        What's next? An international clinical trial led by the Telethon Kids Institute Cancer Centre is trialling a drug which could increase cure rates for ...

        Research

        Unusual paediatric spinal myxopapillary ependymomas: Unique molecular entities or pathological variations on a theme?

        We describe two unusual cases of MPE and use DNA methylation analyses to compare their signatures to try and distinguish if these represent a unique subset. ...

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