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        Research

        Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

        One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern... ...

        Research

        A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources.

        Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular... ...

        Research

        Virus infection and allergy in the development of asthma: What is the connection?

        Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy. ...

        Research

        Attenuation of maternal inflammatory responses during pregnancy to promote normal immune and behavioral outcomes in the offspring

        Deborah Strickland DH PhD Program Head, Immunobiology and Immunotherapeutic Program Deb.Strickland@telethonkids.org.au Program Head, Immunobiology ...

        Research

        Long-term derangement of antigen presenting cell populations in the respiratory tract following Influenza A infection

        Alexander Pat Deborah Larcombe Holt Strickland A PG DH BScEnv (Hons) PhD PhD, DSc, FRCPath, FRCPI, FAA PhD Team Leader, Respiratory Environmental ...

        Research

        Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: A randomised, double-blind, noninferiority trial

        In many countries, infant vaccination with acellular pertussis (aP) vaccines has replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on immunological and epidemiological evidence, we hypothesised that substituting the first aP dose in the routine vaccination schedule with wP vaccine might protect against IgE-mediated food allergy. We aimed to compare reactogenicity, immunogenicity, and IgE-mediated responses of a mixed wP/aP primary schedule versus the standard aP-only schedule. ...

        Research

        Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth

        IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.  ...

        Research

        Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials

        The lack of a consensus definition of neonatal sepsis and a core outcome set proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents. ...

        Research

        A pathogenic role for the integrin CD103 in experimental allergic airways disease

        Role for CD103 in the pathogenesis of experimental allergic airways disease in BALB/c mice through local control of CD4+ T cell and DC subset recruitment ...

        Research

        Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis

        Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell... ...

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