We report a term male with congenital acute erythroleukemia who achieved sustained remission with low-dose cytosine arabinoside alone ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PApilloma TRIal against Cancer In young Adults. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• September 2011

We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

We strive for a future where no child will die from brain cancer because we have developed new therapies that will cure their disease. ...

• Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Cancer Program

Despite initial improvements in survival of infants with ALL since establishment of the first pediatric cooperative group ALL trials, the poor outcome has... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• April 2014

We provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Advancements in genomic profiling led to the discovery of four major molecular subgroups in medulloblastoma (MB), which have now been incorporated into the World Health Organization classification of central nervous system tumors. The current study aimed to determine the prognostic significance of the MB molecular subgroups among children in Malaysia.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022