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        Research

        Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy

        Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus, but whether stretches of differentially methylated regions can also be identified in adolescent GDM offspring is unknown. ...

        Research

        The Promise of Electroencephalography for Advancing Diagnosis and Treatment in Neurodevelopmental Disorders

        Neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, and intellectual disability (ID), commonly emerge during early development and impact functioning across cognitive, social-emotional, communication, and sensorimotor domains. ...

        Research

        Parental occupational exposure to engine exhausts and childhood brain tumors

        Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. ...

        Research

        Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification

        We now have a growing number of epigenetic alterations in disease, and this offers a chance to increase sensitivity and specificity of future diagnostics and therapies ...

        Research

        Frankenstein Cas9: engineering improved gene editing systems

        The discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences. ...

        Research

        The impact of single gene and chromosomal disorders on hospital admissions of children and adolescents: A population-based study

        It is well recognized that genetic disease makes a significant contribution to childhood illness. Here, we present recent population data describing... ...

        2016 Round 2 Seed Funding Recipients

        The Wesfarmers Centre is pleased to announce the successful applications for the 2016 Round 2 Wesfarmers Centre Seed Funding. The Wesfarmers Centre ...

        News & Events

        Community Lecture: Personalised Medicine, the new frontier

        At this special Telethon Kids Institute lecture, Professor Leroy Hood will share his career journey and talk about the emergence of personalised medicine. ...

        News & Events

        Pregnancy risks for ADHD in kids

        One of the largest population studies of Attention Deficit/Hyperactivity Disorder (ADHD) in children has revealed maternal smoking during pregnancy to be an imp ...

        Research

        Tumor Infiltrating Effector Memory Antigen-Specific CD8(+) T Cells Predict Response to Immune Checkpoint Therapy

        Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. ...

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