Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Tim Jones TW MBBS DCH FRACP MD Co-head, Diabetes and Obesity Research Co-head, Diabetes and Obesity Research Areas of research expertise: Diabetes ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

No evidence to demonstrate relationships with symptoms and viruses, prolonged symptoms, prolonged shedding or patterns of virus infections in CF ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

Adolescent deliberate self-harm (DSH) has been found to be associated with a range of bio-psycho-social factors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

Caregivers play a crucial role in supporting the development of their children's emotion regulation. This study validated the Parental Assistance with Child Emotion Regulation (PACER) Questionnaire in a sample of 491 caregivers of young children ≤ 5 years. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

We can all appreciate the benefits of a good night’s sleep, but for premature babies that can be hard to achieve. Their body clocks are not properly ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2022
• Paradigm shift

Exposure to biodiesel exhaust resulted in significantly greater cell death and a greater release of immune mediators compared to both air controls and ULSD exhaust ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

The Telethon Kids Institute is supporting calls for the urgent release of Biloela family from held detention. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2021
• June

Professor Graham Hall says one of the best things about research is seeing his students and colleagues succeed. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2015
• May