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        Research

        Vitamin D in fetal development: Findings from a birth cohort study

        Birth cohort studies provide an invaluable resource for studies of the influence of the fetal environment on health in later life. ...

        Adolescent Health and Wellbeing

        The Adolescent Health and Wellbeing team works in partnership with young people to understand their priority needs and the best ways to address these. This includes informing evidence-based policies and co-designing accessible and responsive health services. ...

        Research

        Mind the distance: experiences of non-face-to-face child and youth mental health services during COVID-19 social distancing restrictions in Western Australia

        Following the outbreak of COVID-19, social distancing restrictions limited access to face-to-face mental health services in Western Australia (WA), necessitating a rapid transition to non-face-to-face alternatives, including telehealth. The current study investigated barriers and facilitators to telehealth access and engagement, and preferences for child and youth mental health service delivery during and beyond COVID-19. ...

        Research

        Nasal delivery of a commensal Pasteurellaceae species inhibits nontypeable Haemophilus influenzae colonisation and delays onset of otitis media in mice

        We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo ...

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        Mailing list Discover. Prevent. Cure. Discover. Prevent. Cure. Mailing list Be Inspired About Telethon Kids Institute About Telethon Kids Institute ...

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        Why tiny dust mites are a big problem

        The molecular studies of Professor Wayne Thomas, particularly on house dust mites, have provided new understandings of allergy and new diagnostics. ...

        Research

        Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma

        Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

        Research

        Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial

        We conducted an open randomized controlled trial in Papua New Guinea to compare safety, immunogenicity and priming for memory of 7-valent PCV (PCV7) given in... ...

        Research

        Exploring quality of life of children with cerebral palsy and intellectual disability: What are the important domains of life?

        An estimated half of all children with cerebral palsy also have comorbid intellectual disability, the domains of QOL for these children are not well understood ...

        Research

        Effectiveness of pneumococcal conjugate vaccine against hospital admissions for pneumonia in Australian children

        Reductions in pneumonia-coded hospital admissions in unvaccinated children predominated in non-Aboriginal children with low incidence of pneumonia ...

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