Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-risk age-group for respiratory infections, remain unclear. We conducted a systematic review and meta-analysis of epidemiological and clinical characteristics of COVID-19 infection in children under five years. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

The 2001 Recommendations for clinical care guidelines on the management of otitis media in Aboriginal and Torres Islander populations were revised in 2010. This 2020 update by the Centre of Research Excellence in Ear and Hearing Health of Aboriginal and Torres Strait Islander Children used for the first time the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

Pneumococcal – a bacterial infection that can cause pneumonia and meningitis – is responsible for thousands of hospital admissions in Australia each ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2023
• Research translation

Tick-associated diseases present challenges due to tridirectional interactions among host-specific responses, tick toxins and salivary proteins as well as microbes. We aimed to uncover molecular mechanisms in tick-bitten skin samples and contralateral skin samples collected simultaneously from the same participants, using spatial transcriptomics. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024

Citation: O'Moore M, Jones B, Hickie M, …….. Marsh JA, Wood N. National pharmacovigilance of seasonal influenza vaccines in Australia. Med J Aust. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024

Streptococcus pyogenes (also known as group A Streptococcus , Strep A) is an obligate human pathogen with significant global morbidity and mortality. Transmission is believed to occur primarily between individuals via respiratory droplets, but knowledge about other potential sources of transmission via aerosols or the environment is limited. Such knowledge is required to design optimal interventions to control transmission, particularly in endemic settings. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection with the most severe disease in the young and elderly. Non-pharmaceutical interventions and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RSV globally, particularly in Australia, where during 2020 the normal winter epidemics were notably absent. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Invasive fungal disease (IFD) remains a challenging complication of treatment for paediatric acute leukaemia. Consensus fungal treatment guidelines recommend withholding chemotherapy to facilitate immune recovery in this setting, yet prolonged delays in leukaemia therapy increase risk of relapse. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

To describe and explore the relationship between weather and the unusual 2020 bronchiolitis season in Western Australia during the COVID-19 pandemic. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022