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        Research

        Meningitis

        Meningitis is when the membranes that surround the brain and spinal cord (meninges) become infected by the bacteria Neisseria meningitidis. ...

        Research

        Screen Time and Parent-Child Talk When Children Are Aged 12 to 36 Months

        Growing up in a language-rich home environment is important for children's language development in the early years. The concept of "technoference" (technology-based interference) suggests that screen time may be interfering with opportunities for talk and interactions between parent and child; however, limited longitudinal evidence exists exploring this association.  ...

        Research

        Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study

        Seasonal malaria chemoprevention (SMC) is recommended for disease control in settings with moderate to high Plasmodium falciparum transmission and currently depends on the administration of sulfadoxine-pyrimethamine plus amodiaquine.  ...

        Research

        Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia

        Burn injuries are devastating traumas, often leading to life-long consequences that extend beyond the observable burn scar. In the context of the nervous system, burn injury patients commonly develop chronic neurological disorders and have been suggested to have impaired motor cortex function, but the long-lasting impact on neurons and glia in the brain is unknown. ...

        Research

        A health inequality analysis of childhood asthma prevalence in urban Australia

        Long-standing health inequalities in Australian society that were exposed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic were described as "fault lines" in a recent call to action by a consortium of philanthropic organizations. With asthma a major contributor to childhood disease burden, studies of its spatial epidemiology can provide valuable insights into the emergence of health inequalities early in life. ...

        Research

        Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

        Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery systems. ...

        Research

        Medical Exemptions to Mandatory Vaccinations: The State of Play in Australia and a Pressure Point to Watch

        Australia’s mandatory vaccination policies have historically allowed for non-medical exemptions, but this changed in 2016 when the Federal Government discontinued non-medical exemptions for childhood vaccination requirements. Australian states introduced further mandatory vaccination policies during the COVID-19 pandemic for a range of occupations including healthcare workers. ...

        Research

        PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

        Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. ...

        Research

        Financial toxicity of informal caregivers of colorectal cancer patients: A cross-sectional study

        To assess the level of financial toxicity of informal caregivers of colorectal cancer patients and explore the related key influencing factors. ...

        Research

        Airway management in neonates and infants: Recommendations according to the ESAIC/BJA guidelines

        Securing an airway enables the oxygenation and ventilation of the lungs and is a potentially life-saving medical procedure. Adverse and critical events are common during airway management, particularly in neonates and infants. The multifactorial reasons for this include patient-dependent, user-dependent and also external factors. ...

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