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        Research

        Cardio-Oncology Recommendations for Pediatric Oncology Patients: An Australian and New Zealand Delphi consensus

        Cardio-oncology is a new multidisciplinary area of expertise that seeks to pre-emptively and proactively address cardiac complications that emerge during and following cancer therapy. Modern therapies including molecular targeted therapy and immunotherapy have broadened the agents that can cause cardiac sequelae, often with complications arising within days to weeks of therapy. ...

        Research

        Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma

        Central nervous system germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus have proven challenging to treat given their rarity and poorly defined imaging characteristics. Craniospinal, whole brain, whole ventricle, and focal RT have all been utilized; however, the best treatment strategy remains unclear. ...

        Research

        Medulloblastoma

        Medulloblastoma is a highly malignant small round blue cell tumor of the posterior fossa ...

        News & Events

        Why timing matters: How tumours respond to immunotherapy treatments over time

        Researchers have identified key differences between cancers that respond to immunotherapy and those that do not. ...

        Research

        Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication

        We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols to determine... ...

        Research

        Meningiomas in children and adolescents: a meta-analysis of individual patient data

        The epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined... ...

        Research

        Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiation

        This study investigates the different patterns of relapse in patients with central nervous system mixed malignant germ cell tumors - treated with chemotherapy. ...

        Research

        Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiation

        This study investigated the relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated with chemotherapy-only ...

        News & Events

        Telethon Adventurers fund new brain tumour research fellowship

        The Telethon Adventurers have announced a new research fellowship to investigate the genes involved in childhood brain tumours. ...

        Research

        CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy

        While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors. ...

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