Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphoblastic leukemia (T-ALL) mainly occurs at promoters of Polycomb Repressor Complex 2 (PRC2) target genes that are not expressed in normal or malignant T-cells and which display a reciprocal association with H3K27me3 binding. ...

• 1. Telethon Kids Institute
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• 2020
• November 2020

The Opportunity The Oncogenic Signalling Laboratory is a collaborative group composed of clinical and lab-based researchers focused on the goal of ...

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Brain tumors presenting in infancy, especially during the first 6 months of life. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2012
• September 2012

The epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined... ...

• 1. Telethon Kids Institute
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• 2011
• November 2011

We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols to determine... ...

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• 2015
• June 2015

While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors. ...

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• 2022
• December 2022

This study defines PFS and OS, and is the first describe post-progression survival in a large cohort of children with DIPG. ...

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• 2017
• September 2017

Genomic information is increasingly used to inform medical treatments and manage future disease risks. However, any personal and societal gains must be carefully balanced against the risk to individuals contributing their genomic data. Expanding our understanding of actionable genomic insights requires researchers to access large global datasets to capture the complexity of genomic contribution to diseases. ...

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• 2024
• January 2024

A higher incidence of pediatric intracranial germ cell tumors (iGCTs) in Asian countries compared with Western countries has been reported. In Malaysia, the literature regarding pediatric iGCTs have been nonexistent. The aim of this study was to review the management, survival, and long-term outcomes of pediatric iGCTs at a single tertiary center in Malaysia. ...

• 1. Telethon Kids Institute
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• 2021
• October 2021