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        Research

        Detection of bile acids in bronchoalveolar lavage fluid defines the inflammatory and microbial landscape of the lower airways in infants with cystic fibrosis

        Cystic Fibrosis (CF) is a genetic condition characterized by neutrophilic inflammation and recurrent infection of the airways. How these processes are initiated and perpetuated in CF remains largely unknown. We have demonstrated a link between the intestinal microbiota-related metabolites bile acids and inflammation in the bronchoalveolar lavage fluid from children with stable CF lung disease. ...

        Research

        An update on the burden of group A streptococcal diseases in Australia and vaccine development

        Asha Bowen AC BA MBBS DCH FRACP PhD GAICD OAM Head, Healthy Skin and ARF Prevention Head, Healthy Skin and Arf Prevention Areas of expertise: Skin ...

        Research

        Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPD

        We propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes ...

        Research

        Catalyst Twenty-Twenty: Post-Traumatic Growth at Scales of Person, Place and Planet

        Planetary health is a broad multidisciplinary effort that attempts to address what has been described as “Anthropocene Syndrome”—the wicked, interrelated challenges of our time. These include, but are not limited to, grotesque biodiversity losses, climate change, environmental degradation, resource depletion, the global burden of non-communicable diseases (NCDs), health inequalities, social injustices, erosion of wisdom and civility, together with the many structural underpinnings of these grand challenges. ...

        Research

        Cord blood t cells expressing high and low pkcζ levels develop into cells with a propensity to display th1 and th9 cytokine profiles, respectively

        ow Protein Kinase C zeta (PKCζ) levels in cord blood T cells (CBTC) have been shown to correlate with the development of allergic sensitization in childhood. However, little is known about the mechanisms responsible. We have examined the relationship between the expression of different levels of PKCζ in CBTC and their development into mature T cell cytokine producers that relate to allergy or anti‐allergy promoting cells. ...

        Research

        Disparities in severe neonatal morbidity and mortality between Aboriginal and non-Aboriginal births in Western Australia: a decomposition analysis

        The health disadvantages faced by Australian Aboriginal peoples are evidenced in early life, although few studies have focused on the reasons for population-level inequalities in more severe adverse outcomes. This study aimed to examine the scale of disparity in severe neonatal morbidity (SNM) and mortality between Aboriginal and non-Aboriginal births and quantify the relative contributions of important maternal and infant factors. ...

        Research

        The impact of child maltreatment on the risk of deliberate self-harm among adolescents: A population-wide cohort study using linked administrative records

        This study calls for the early identification of children who are vulnerable to maltreatment, the better identification of the duration and severity of maltreatment experiences, and the provision of continued care and support, to reduce the child's deliberate self harm risk in adolescence. ...

        Research

        High-Rise Apartments and Urban Mental Health—Historical and Contemporary Views

        High-rise apartment buildings have long been associated with the poor mental health of their residents ...

        Research

        Out-of-Home Care and the Educational Achievement, Attendance, and Suspensions of Maltreated Children: A Propensity-Matched Study

        Out-of-home care was not found to be a significant factor in the adverse educational outcomes of these children ...

        Research

        Maternal Work–Family Conflict and Psychological Distress: Reciprocal Relationships Over 8 Years

        Employed mothers may benefit from policies and workplace practices that promote maternal well-being and reduce conflicts between employment and raising children ...

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