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        Research

        Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

        Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warrant the urgent development of more effective and cancer-selective therapeutics. ...

        Research

        Lung inflammation and simulated airway resistance in infants with cystic fibrosis

        Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. ...

        Research

        Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemia

        Our findings shed light on the mechanisms of leukemia-induced bone loss ...

        Research

        Environmental and social determinants of acute rheumatic fever: a longitudinal cohort study

        Prevention strategies in ARF endemic settings may be enhanced by targeting new members entering a community and children in environments of close contact ...

        Research

        The impact of respiratory viruses on lung health after preterm birth

        The aim of this review is to highlight the risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants ...

        Research

        The effect of endotracheal tubes versus laryngeal mask airways on perioperative respiratory adverse events in infants: A randomised controlled trial

        Evaluating the difference of the effects of Laryngeal mask airways compared to endotracheal tubes in older children (>1 year) in incidents of PRAE in infants. ...

        Research

        Respiratory function and symptoms in young preterm children in the contemporary era

        Preterm children have worse lung function than healthy controls ...

        Research

        Is headspace making a difference to young people’s lives?

        This report presents the evaluation findings of headspace, a service to improve the mental health and social and emotional wellbeing of young people ...

        Research

        Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis

        Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell... ...

        News & Events

        Rapid response to e-cigarette findings

        Telethon Kids Institute-led research revealing that six out of 10 nicotine free e-cigarette liquids contained nicotine and other potentially harmful chemicals. ...

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