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        Research

        Factors Influencing Parental Acceptance of Trans Children and Young People: Findings from Trans Pathways

        Trans youth are at high risk of mental health difficulties and negative life events. Strong parental support is highly protective however there is little understanding of what factors facilitate the process of parental understanding and acceptance of a child’s gender identity. ...

        Research

        Effectiveness, Acceptability, and Feasibility of Digital Health Interventions for LGBTIQ+ Young People: Systematic Review

        Young people (aged 12-25 years) with diverse sexuality, gender, or bodily characteristics, such as those who identify as lesbian, gay, bisexual, transgender, intersex, or queer (LGBTIQ+), are at substantially greater risk of a range of mental, physical, and sexual health difficulties compared with their peers. Digital health interventions have been identified as a potential way to reduce these health disparities. ...

        Research

        Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis

        Our data provide insight into the molecular mechanisms underpinning the association of HLA-DRB1 alleles with risk versus protection in visceral leishmaniasis in humans ...

        Research

        Burkholderia pseudomallei evades Nramp1 (Slc11a1)- and NADPH oxidase-mediated killing in macrophages and exhibits Nramp1-dependent virulence gene expression

        Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei. ...

        Research

        Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil

        Here we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis... ...

        Research

        Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients

        Uniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence ...

        Research

        A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis

        The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. ...

        Research

        CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

        To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration.. ...

        Case Study: NEC

        Procurement and Supply Partner Queries Corporate Philanthropy For any procurement queries, please contact the Institute's Procurement Team. Emma ...

        Research

        Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India

        Amphotericin B provides improved therapy for visceral leishmaniasis (VL) caused by Leishmania donovani ...

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