Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global mortality, often associated with high blood levels of LDL cholesterol (LDL-c). Medications like statins and PCSK9 inhibitors, are used to manage LDL-c levels and reduce ASCVD risk. Recent findings connect the gut microbiota and its metabolites to ASCVD development. ...

• Telethon Kids Institute
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• Reports and Findings
• 2024
• January 2024

Antimicrobial resistance poses a significant threat to modern healthcare as it limits treatment options for bacterial infections, particularly impacting those with chronic conditions such as cystic fibrosis (CF). Viscous mucus accumulation in the lungs of individuals genetically predisposed to CF leads to recurrent bacterial infections, necessitating prolonged antimicrobial chemotherapy. Pseudomonas aeruginosa infections are the predominant driver of CF lung disease, and airway isolates are frequently resistant to multiple antimicrobials. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Severity and disease progression in people with Cystic Fibrosis is typically dependent on their genotype. One potential therapeutic strategy for people with specific mutations is exon skipping with antisense oligonucleotides. CFTR exon 9 is an in-frame exon and hence the exclusion of this exon would excise only 31 amino acids but not alter the reading frame of the remaining mRNA. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

SARS-CoV-2 infection rapidly spreads in populations due to the high rates of community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence of Coronavirus Disease 19 (COVID-19). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

Clinical trials for the treatment of cystic fibrosis (CF) lung disease are important to test and optimise new therapeutic interventions. ...

• Telethon Kids Institute
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• Reports and Findings
• 2013
• September 2013

The transition to school can be an exciting but also uncertain time for children and families. We know many children with autism may be more sensitive to transitions so may need some extra supports at this time. ...

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Hayley Liz Gina Pulan Zino Christian Wenden Trapp Bai Phiri HC LW GT PB ZP BSc (1st Class Hons), PhD W.Aust. BHlthSc MPH BHSc(Hons1A), RPHNutr, PhD ...

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Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping" ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

Irritability is a transdiagnostic indicator of child and adolescent internalizing and externalizing problems that is measurable from early life. The objective of this systematic review was to determine the strength of the association between irritability measured from 0 to 5 years and later internalizing and externalizing problems, to identify mediators and moderators of these relationships, and to explore whether the strength of the association varied according to irritability operationalization. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Early intervention is being touted as the key to preventing lung damage in children with cystic fibrosis. ...

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• 2015
• June