Measles virus causes severe morbidity and mortality, despite the availability of measles vaccines. Successful defence against viral pathogens requires early... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• June 2012

We identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Despite the use of measles vaccine, measles virus continues to circulate and cause severe disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

This study advances our understanding of drug resistance in T-ALL and provides new markers for patient stratification. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; however, mechanistic and functional validation of these mutations is lacking. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

Clinical Trials, Platforms & Cohorts Discover. Prevent. Cure. Community and patient cohorts Enabling us to undertake a world-class program in ...

• Wal-yan Respiratory Research Centre
• Our research

Middle ear infections are one of the main reasons that children visit a GP, are prescribed antibiotics and need surgery. Aboriginal children are particularly susceptible and commonly suffer from hearing loss which can affect speech and learning. ...

• 1. Telethon Kids Institute
• Our research
• Research Topics

CDKL5 Deficiency Disorder (CDD) is a rare genetic disorder caused by a mutation in the cyclin-dependent kinase-like 5 (CDKL5) gene. It is now considered to be a developmental and epileptic encephalopathy because of the early onset of seizures in association with severe global delay. Other features include cortical visual impairment, sleep and gastro-intestinal problems. Progress in clinical understanding, especially regarding the spectrum of functional ability, seizure patterns, and other comorbidities was initially slow but accelerated in 2012 with the establishment of the International CDKL5 Database (ICDD). Our aim was to use this data source to investigate quality of life (QOL) and associated factors in this disorder. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021