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        Long-term outcome of insulin pump therapy in children with type 1 diabetes assessed in a large population-based case-control study

        We determined the impact of insulin pump therapy on long-term glycaemic control, BMI, rate of severe hypoglycaemia and diabetic ketoacidosis (DKA) in children. ...

        Research

        The effect of midday moderate-intensity exercise on postexercise hypoglycemia risk in individuals with type 1 diabetes

        Recently we reported a biphasic increase in glucose requirements to maintain euglycemia after late-afternoon exercise, suggesting a unique pattern of delayed... ...

        Research

        Dietary intake of omega-3 fatty acids and risk of depressive symptoms in adolescents

        Previous randomized controlled trials have demonstrated that omega-3 polyunsaturated fatty acids (n-3 PUFA) are beneficial in reducing symptoms of depression. ...

        Proportion of Emergency Department presentations for deliberate self-harm in children and young people

        Policy Context Indicator Information View the Maps Mental health disorders are the most common chronic conditions experienced by young people in the ...

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        Evaluating the genetic contribution to rheumatic heart disease pathogenesis in Australian Aboriginal and Torres Strait Islander communities

        Jenefer Jonathan Blackwell Carapetis AM JM JR BSc with First Class Honours, PhD, DSc, FMedSci, FAA AM MBBS FRACP FAFPHM PhD FAHMS Head, Genetics & ...

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        Pets Are Associated with Fewer Peer Problems and Emotional Symptoms, and Better Prosocial Behavior: Findings from the Longitudinal Study of Australian Children

        Pets may protect children from developing social-emotional problems and should be taken into account when assessing child development and school readiness ...

        Research

        Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly

        The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation. ...

        Research

        Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal Population

        Our goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians. ...

        Research

        Toxoplasma gondii infection is associated with mitochondrial dysfunction in-vitro

        Our results show perturbation of host mitochondrial function following T. gondii infection that likely impacts on pathogenesis of disease. ...

        Research

        Unraveling the genetics of otitis media: From mouse to human and back again

        Otitis media (OM) is among the most common illnesses of early childhood, characterised by the presence of inflammation in the middle ear cavity... ...

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