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        Research

        Inflammation induces α1-adrenoceptor expression in peripheral blood mononuclear cells of patients with complex regional pain syndrome

        Persistent regional and systemic inflammation may promote pain and hyperalgesia in complex regional pain syndrome. In this study, we investigated whether stimulation of α1-adrenoceptors on peripheral blood mononuclear cells might contribute to this inflammatory state. ...

        Research

        Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

        With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity. ...

        Research

        Prevalence of chronic respiratory diseases in Aboriginal children: A whole population study

        The burden of bronchiectasis is disproportionately high in Aboriginal adults, with early mortality. Bronchiectasis precursors, that is, protracted bacterial bronchitis and chronic suppurative lung disease, often commence in early childhood. ...

        Research

        Suicide prevention in LGBTQA+ young people: Best practice guidelines for clinical and community service providers

        Penelope Larissa Zoe Yael MEDIA ENQUIRIES Strauss Marion Waters Perry Media Contacts PS LM ZW YP How to use the guidelines Glossary Important Dates ...

        Research

        Youth Suicide Prevention Modelling Project

        Jacinta Freeman JF BScs, MPH Program Manager, Youth Mental Health 6319 1699 Jacinta.freeman@telethonkids.org.au Program Manager she/her/hers Jacinta ...

        News & Events

        Free nutrition & lifestyle program for new mums

        Telethon Kids Institute researchers are offering a free nutrition and lifestyle program for plus sized mums and their babies who live in the Joondalup area. ...

        Research

        Variation in treatment preferences of pulmonary exacerbations among Australian and New Zealand cystic fibrosis physicians

        Despite advances in cystic fibrosis (CF) management and survival, the optimal treatment of pulmonary exacerbations remains unclear. Understanding the variability in treatment approaches among physicians might help prioritise clinical uncertainties to address through clinical trials. ...

        Research

        Paediatric headbox as aerosol and droplet barrier

        High-flow nasal oxygen (HFNO) is frequently used in hospitals, producing droplets and aerosols that could transmit SARS-CoV-2. Our aim was to determine if a headbox could reduce droplet and aerosol transmission from patients requiring HFNO. ...

        Research

        Risk Factors for Gut Dysbiosis in Early Life

        Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbiosis of the intestinal microbiota can have a substantial effect on the nervous and immune systems, contributing to the onset of several inflammatory diseases. ...

        Research

        Side effects of medications used to treat childhood interstitial lung disease

        Interstitial lung disease in children comprises a range of different rare diseases ...

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