Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Interfant-06 protocol, which compared lymphoid-style consolidation (protocol IB) versus myeloid-style consolidation (araC, daunorubicin, etoposide/mitoxantrone, araC, etoposide). ...

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• 2021
• February 2021

We investigated the relationship between the sensitivity of hundreds of cell lines to hundreds of drugs, and the relative expression levels of the targets ...

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• 2019
• December 2019

Program Coordinator ...

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The control arm of PATRICIA (PApillomaTRIal against Cancer In young Adults, NCT00122681) was used to investigate the risk of progression from cervical HPV... ...

• 1. Telethon Kids Institute
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• 2014
• November 2014

Increased risks were observed for maternal exposure to diesel exhaust any time before the child's birth and paternal exposure around the time of the child's... ...

• 1. Telethon Kids Institute
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• 2013
• June 2013

Genomic information is increasingly used to inform medical treatments and manage future disease risks. However, any personal and societal gains must be carefully balanced against the risk to individuals contributing their genomic data. Expanding our understanding of actionable genomic insights requires researchers to access large global datasets to capture the complexity of genomic contribution to diseases. ...

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• 2024
• January 2024

I review recent high-profile court cases to underscore the changing landscape of conflict and the central role that the media (and social media in particular) can play ...

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• 2020
• January 2020

A higher incidence of pediatric intracranial germ cell tumors (iGCTs) in Asian countries compared with Western countries has been reported. In Malaysia, the literature regarding pediatric iGCTs have been nonexistent. The aim of this study was to review the management, survival, and long-term outcomes of pediatric iGCTs at a single tertiary center in Malaysia. ...

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• 2021
• October 2021

This study defines PFS and OS, and is the first describe post-progression survival in a large cohort of children with DIPG. ...

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• 2017
• September 2017

We were honoured to hear the story of the incredible Darcey Brooks who is tackling the Rottnest Channel Swim this Saturday to help raise money for research here at Telethon Kids. ...

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• 2022
• February