This multinational study presents unique body mass index z score trajectories in youth with type 1 diabetes across three continents ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Nutrition is one of the most easily modifiable environmental factors during early life that may play a role in allergic disease prevention. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

NDD's such as ASD, ADHD and ID, commonly emerge during early development and impacts function across cognitive, social-emotional, communication and sensorimotor ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

Our results suggest that maternal prenatal use of vitamins and folic acid reduces the risk of both ALL and AML ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

Discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and endoplasmic reticulum genes identified in a whole-genome CRISPR knockout screen for inducers of mitochondrial biogenesis stress, showing that defects in peroxisome, Golgi and endoplasmic reticulum metabolism disrupt mitochondrial structure and function.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Atopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date combining previously reported cohorts with additional available data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Canonical RNA processing in mammalian mitochondria is defined by tRNAs acting as recognition sites for nucleases to release flanking transcripts. The relevant factors, their structures, and mechanism are well described, but not all mitochondrial transcripts are punctuated by tRNAs, and their mode of processing has remained unsolved. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022