Upper and lower airways are conserved in their transcriptional composition, and variations associated with disease are present in both nasal and tracheal epithelium ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

We demonstrate that NOTCH3 is a regulator of MUC5AC production ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Several lipid biomarkers of early cystic fibrosis lung disease were identified, which point toward potential disease monitoring and therapeutic approaches ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

This review summarises the phage-microbe-human lung interactions in CF that must be addressed to successfully develop and deliver phage to CF airways ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

This review attempts to highlight migration-specific and cell-extracellular matrix (ECM) aspects of repair used by epithelial cells ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

In human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

The study of small airway diseases such as post-transplant bronchiolitis obliterans syndrome (BOS) is hampered by the difficulty in assessing peripheral airway ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• October 2009

Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an invasive pleural model with a non-invasive subcutaneous model of mesothelioma and performed transcriptomic analyses on the tumour samples. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate IFN response associated with disease severity. Our objective was to examine the prophylactic potential of IFN administration to limit viral transmission. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023