Antimicrobial resistance poses a significant threat to modern healthcare as it limits treatment options for bacterial infections, particularly impacting those with chronic conditions such as cystic fibrosis (CF). Viscous mucus accumulation in the lungs of individuals genetically predisposed to CF leads to recurrent bacterial infections, necessitating prolonged antimicrobial chemotherapy. Pseudomonas aeruginosa infections are the predominant driver of CF lung disease, and airway isolates are frequently resistant to multiple antimicrobials. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Severity and disease progression in people with Cystic Fibrosis is typically dependent on their genotype. One potential therapeutic strategy for people with specific mutations is exon skipping with antisense oligonucleotides. CFTR exon 9 is an in-frame exon and hence the exclusion of this exon would excise only 31 amino acids but not alter the reading frame of the remaining mRNA. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

We hypothesized that the presence of these markers of cystic fibrosis lung disease in the first 2 years of life would be associated with reduced lung... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

André Anthony Stephen Schultz Kicic Stick AS A SM MBChB, PhD, FRACP BSc (Hons) PhD MB BChir PhD MRCP FRACP Program Head, Respiratory Health RFA ...

• 1. Telethon Kids Institute
• Projects

Graham Shannon Stephen Hall Simpson Stick GL SS SM BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (hons), PhD MB BChir PhD MRCP FRACP Honorary ...

• 1. Telethon Kids Institute
• Projects
• Past projects

Chest CT identifies children at an early age who have adverse long-term outcomes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25-75 in children with CF ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for clinical practice and research ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• June 2017

Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

Stephen Graham Elizabeth Stick Hall Smith SM GL ES MB BChir PhD MRCP FRACP BAppSci PhD CRFS FANZSRS FThorSoc FERS PhD, MSc, BSc Head, P4 Respiratory ...

• 1. Telethon Kids Institute
• Projects