Recent preclinical data show that sodium glucose cotransporter 2 (SGLT2) inhibitors are able to reduce weight gain and induce beiging in white adipose tissue (WAT). We have previously shown that in neurogenic hypertensive Schlager (BPH/2J) mice, treatment with the SGLT2 inhibitor, Dapagliflozin, reduced blood pressure and prevented weight gain. Here we show that chemical sympathetic denervation achieved by systemic administration of 6-hydroxy-dopamine (6-OHDA) reduces body weight and the heightened sympathetic nervous system (SNS) innervation in WAT. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

I review recent high-profile court cases to underscore the changing landscape of conflict and the central role that the media (and social media in particular) can play ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Have you seen the recent news about Type1Screen, a free new nationwide program that aims to better detect a child's risk of developing type 1 diabetes? ...

• Rio Tinto Children's Diabetes Centre
• News and events

The most recent global estimates of the number of pregnancies at risk of Plasmodium falciparum and Plasmodium vivax malaria infection are from 2007. To inform global malaria prevention and control efforts, we aimed to estimate the global distribution of pregnancies at risk of malaria infection from 2007 to 2020. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Nirsevimab is an extended half-life monoclonal antibody to the respiratory syncytial virus (RSV) fusion protein that has been developed to protect infants for an entire RSV season. Previous studies have shown that the nirsevimab binding site is highly conserved. However, investigations of the geotemporal evolution of potential escape variants in recent (ie, 2015–2021) RSV seasons have been minimal. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Our findings demonstrate that Ultra-High-Risk groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

Honorary Community Co-Researcher ...

• 1. Telethon Kids Institute
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• Our people
• Staff Profiles - A

The recent announcement of the negative results of the TIGER- 2 phase 3 study of denufosol tetrasodium ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

In this review, we discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

The recent discovery of emerging relapsing fever group Borrelia (RFGB) species, such as Borrelia miyamotoi, poses a growing threat to public health. However, the global distribution and associated risk burden of these species remain uncertain. We aimed to map the diversity, distribution, and potential infection risk of RFGB.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• March 2024