Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

GWAS analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis suggested shared genetic mechanisms across rhinitis-related traits ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

This review article addresses the driving factors associated with diagnosis and treatment of sore throats caused by Group A streptococcus. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• June 2015

Aboriginal and Torres Strait Islander Australians experience stroke and traumatic brain injury (TBI) with much greater frequency than non-Aboriginal Australians ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

new research at Telethon Kids Institute will look at the diets of mums to see if regularly eating more eggs or peanuts during pregnancy and while breastfeeding ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2017
• December

Our Project Management Team Get in Touch Get in touch with The ORIGINS Project team ORIGINSproject@telethonkids.org.au Find us at one of our two ...

• The ORIGINS Project
• About ORIGINS

Enhancing psychological wellbeing in families from pregnancy to infancy ...

• The ORIGINS Project
• Sub-projects
• Parenting

We’re super excited to welcome Dr Amelia Harray to our research team. Amelia looks forward to strengthening the focus on food research to help children with type 1 diabetes and their families. ...

• Rio Tinto Children's Diabetes Centre
• News and events

Multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are major public health threats that are significant causes of physical sequelae and financial consequences for infected people. Treatment for MDR- and XDR-TB are more toxic and take longer duration than for drug-susceptible-TB. As a result, the long-term sequelae are thought to be more common among patients with MDR- and XDR-TB than drug-susceptible-TB, but this is yet to be quantified. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Developing new methods for modelling infectious diseases outbreaks is important for monitoring transmission and developing policy. In this paper we propose using semi-mechanistic Hawkes Processes for modelling malaria transmission in near-elimination settings. Hawkes Processes are well founded mathematical methods that enable us to combine the benefits of both statistical and mechanistic models to recreate and forecast disease transmission beyond just malaria outbreak scenarios. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021