In this investigation, the authors found an association between home pesticide exposure before birth and during a child's early years and acute lymphoblastic... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• December 2015

Connective tissue growth factor (CTGF/CCN2) has been shown previously to be aberrantly expressed in a high proportion of paediatric precursor B cell acute... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• May 2015

Biological changes associated with T-ALL relapse and resistance are stochastic and highly individual ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• August 2016

An improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• March 2011

Participation in population-based case-control studies: does the observed decline vary by socio-economic status? ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• October 2011

The association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

We explored familial aggregation of cancer in a population-based case-control study using genealogical record linkage and designed to overcome limitations of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• June 2013

Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity ...

• 1. Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Diabetes, Metabolism and Clinical Sciences
• Diabetes and Obesity Research
• Expired Projects

Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mitochondrial proteomes.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome requires separate enzymatic activities that can sterically compete, suggesting a life-long trade-off between these two processes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023