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        Research

        Risk factors associated with RSV hospitalisation in the first 2 years of life, among different subgroups of children in NSW

        Data on risk factors for respiratory syncytial virus (RSV)-associated hospitalisation in Australian children may be informative for preventive measures. ...

        Research

        Evaluating the use and effectiveness of passive immunization in reducing RSV-associated morbidity in high risk infants

        Hannah Tom Moore Snelling HC T OAM BSc (Hons) GradDipClinEpi PhD BMBS DTMH GDipClinEpid PhD FRACP Program Head, Infection and Vaccines Head, ...

        Research

        Changing rules, recommendations, and risks: COVID-19 vaccination decisions and emotions during pregnancy

        As COVID-19 vaccinations rolled out globally from late 2020, rules and recommendations regarding vaccine use in pregnancy shifted rapidly. Pre-registration COVID-19 vaccine trials excluded those who were pregnant. Initial Australian medical advice did not routinely recommend COVID-19 vaccines in pregnancy, due to limited safety data and little perceived risk of local transmission. ...

        Research

        Randomised controlled trials of behavioural nudges delivered through text messages to increase influenza and COVID-19 vaccines among pregnant women (the EPIC study): study protocol

        Influenza and COVID-19 infections during pregnancy may have serious adverse consequences for women as well as their infants. However, uptake of influenza and COVID-19 vaccines during pregnancy remains suboptimal. This study aims to assess the effectiveness of a multi-component nudge intervention to improve influenza and COVID-19 vaccine uptake among pregnant women.  ...

        Research

        Pertussis Disease and Antenatal Vaccine Effectiveness in Australian Children

        Population-level studies of severe pertussis extending beyond infancy are sparse, and none in the context of antenatal vaccination. We compared hospitalized pertussis cases from birth to 15 years of age before and after introduction of antenatal immunization. ...

        Research

        Prediction of Causative Pathogen of Osteomyelitis Using Bayesian Network Modelling

        Asha Christopher Tom Bowen Blyth Snelling AC CC T BA MBBS DCH FRACP PhD GAICD MBBS (Hons) DCH FRACP FRCPA PhD BMBS DTMH GDipClinEpid PhD FRACP Team ...

        Research

        Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

        Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. ...

        News & Events

        Australia Day Honours for researchers and esteemed Elder

        Four outstanding members of the Telethon Kids Institute family – three researchers and an Aboriginal Elder co-researcher – have been named in the Australia Day Honours List for their outstanding service to research and the community. ...

        Research

        AusVaxSafety

        Christopher Peter Peter Tom Blyth Jacoby Richmond Snelling CC PJ PC T MBBS (Hons) DCH FRACP FRCPA PhD BA (Hons) MSc MBBS MRCP(UK) FRACP BMBS DTMH ...

        Research

        A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial

        The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. ...

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