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        Research

        Helicobacter pylori overcomes natural immunity in repeated infections

        Helicobacter pylori infection does not promote an immune response protective against future reinfection ...

        Research

        The stark reality of rheumatic heart disease

        This editorial refers to ‘Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart... ...

        Research

        Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice

        In addition to providing pathogen-specific immunity, vaccines can also confer nonspecific effects (NSEs) on mortality and morbidity unrelated to the targeted disease. Immunisation with live vaccines, such as the BCG vaccine, has generally been associated with significantly reduced all-cause infant mortality. In contrast, some inactivated vaccines, such as the diphtheria, tetanus, whole-cell pertussis (DTPw) vaccine, have been controversially associated with increased all-cause mortality especially in female infants in high-mortality settings. ...

        National Vaccines Platform – First Nations Community Advisory group

        Telethon Kids Institute is leading the development of a National Vaccine Platform for conducting trials to improve protection from diseases that can prevented with vaccines. We are seeking Aboriginal and/or Torres Strait Islanders to join our new First Nations Vaccines Community Advisory Group. ...

        News & Events

        Children sought for study into how to prevent sore throats

        More than 1000 children are being sought for a study to learn more about sore throats and how best to prevent them. ...

        Research

        Continued challenge of rheumatic heart disease: The gap of understanding or the gap of implementation?

        We still do not have a RF vaccine, although the recent announcement that the Australian and New Zealand governments are jointly sponsoring a program to fast... ...

        Research

        Immunization of newborns with bacterial conjugate vaccines

        Bacterial conjugate vaccines are based on the principle of coupling immunogenic bacterial capsular polysaccharides to a carrier protein to facilitate the... ...

        Research

        OPTIMUM: OPTimising IMmunisation Using Mixed schedules

        Pat Peter Susan Tom Jennifer Holt Richmond Prescott Snelling Kent PG PC SL T J PhD, DSc, FRCPath, FRCPI, FAA MBBS MRCP(UK) FRACP MBBS BMedSci PhD ...

        Research

        Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

        Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects. ...

        Research

        Clinical predictors of hypoxic pneumonia in children from the Eastern Highlands Province, Papua New Guinea: secondary analysis of two prospective observational studies

        Pneumonia is the leading cause of death in young children globally and is prevalent in the Papua New Guinea highlands. We investigated clinical predictors of hypoxic pneumonia to inform local treatment guidelines in this resource-limited setting. ...

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