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        Research

        The role of coping in the association between subclinical psychotic experiences and functioning: A within study replication in two independent adolescent samples

        The within study replication consistently found that coping style mediates subclinical psychotic experiences and psychosocial functioning ...

        Research

        Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

        Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors ...

        Research

        Investigation of group A Streptococcus immune responses in an endemic setting, with a particular focus on J8

        We analysed the stimulation of J8 antibodies in response to infection, and the role of existing J8 antibodies in protection against subsequent infection ...

        Research

        Childhood pneumonia and meningitis in the Eastern Highlands Province, Papua New Guinea in the era of conjugate vaccines: study methods and challenges

        Recruitment of large numbers of pediatric pneumonia and meningitis cases and community controls in a third-world setting presents unique challenges ...

        Research

        Clinical development strategy for a candidate group A streptococcal vaccine

        This review outlines a clinical development strategy detailing the phases of development required for registration of a candidate Group A streptococci vaccin ...

        Research

        Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.

        We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria. ...

        Research

        The role of PKCzeta in cord blood T-cell maturation towards Th1 cytokine profile and its epigenetic regulation by fish oil

        Here, we present evidence that there are two major control points to explain the immunodeficiency in CB T-cells, leading to a decreased IFNy synthesis. ...

        Research

        Physician training programs significantly improve diagnosis in cases coded as anaphylaxis over time: A major factor compounding time-trend data?

        Recent studies based on hospital admissions have reported a significant increase in anaphylaxis prevalence. ...

        Research

        Pulmonary delivery of virosome-bound antigen enhances antigen-specific CD4+ T cell proliferation compared to liposome-bound or soluble antigen

        Pulmonary administration of biomimetic nanoparticles loaded with antigen may represent an effective strategy to directly modulate adaptive immune responses ...

        Research

        ‘Is it like one of those infectious kind of things?’ The importance of educating young people about HPV and HPV vaccination at school

        Greater knowledge and understanding of National Human Papillomavirus vaccination appeared to promote positive attitudes towards vaccination ...

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