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        Research

        Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis

        Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell... ...

        News & Events

        Rapid response to e-cigarette findings

        Telethon Kids Institute-led research revealing that six out of 10 nicotine free e-cigarette liquids contained nicotine and other potentially harmful chemicals. ...

        News & Events

        Whooping cough vaccine could be a new weapon in the fight against food allergies

        Researchers from the Telethon Kids Institute and Curtin University will use a $3.9 million grant from the National Health and Medical Research Council to investigate whether a type of whooping cough vaccine could provide bonus protection against food allergies and eczema. ...

        Research

        Pharmacokinetics of intramuscular versus subcutaneous administration of Benzathine Penicillin G

        Jonathan Rosemary Carapetis AM Wyber JR R AM MBBS FRACP FAFPHM PhD FAHMS MBChB MPH FRACGP PhD Executive Director; Head, Strep A Translation; ...

        News & Events

        Child health and obesity the focus of international built environment study

        Research data from more than one million Australian and Welsh children will be examined to help better understand how the built environment affects child health and obesity, as part of an international research project to be co-led by the Telethon Kids Institute. ...

        Research

        Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

        Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphoblastic leukemia (T-ALL) mainly occurs at promoters of Polycomb Repressor Complex 2 (PRC2) target genes that are not expressed in normal or malignant T-cells and which display a reciprocal association with H3K27me3 binding. ...

        Research

        Effect of Albuterol Premedication vs Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: The REACT Randomized Clinical Trial

        Determine whether inhaled albuterol sulfate (salbutamol sulfate) premedication decreases the risk of perioperative respiratory adverse events ...

        Research

        Persistent and progressive long-term lung disease in survivors of preterm birth

        This review aims to summarise what is known about the long-term pulmonary outcomes of contemporary preterm birth ...

        Research

        Increased prevalence of expiratory flow limitation during exercise in children with bronchopulmonary dysplasia

        Expiratory flow limitation is more prevalent in children born preterm with bronchopulmonary dysplasia and is associated with airway obstruction ...

        Research

        Deep or awake removal of laryngeal mask airway in children at risk of respiratory adverse events undergoing tonsillectomy - a randomised controlled trial

        We found no evidence for a difference in the timing of the laryngeal mask airways removal on the incidence of respiratory adverse events ...

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