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        Research

        Vehicle refuelling, use of domestic wood heaters and the risk of childhood brain tumours: Results from an Australian case-control study

        The aetiology of childhood brain tumours (CBT) is largely unknown. ...

        Research

        Plasma micronutrient levels and telomere length in children

        Telomeres are long hexamer (TTAGGG) repeats at the ends of chromosomes, and contribute to maintenance of chromosomal stability. ...

        Research

        The broader language phenotype of Autism: A comparison with Specific Language Impairment

        Some individuals with autism spectrum disorders (ASD) experience linguistic difficulties similar to those found in individuals with specific language... ...

        Research

        Assessment of the potency and potential immunomodulatory effects of the Measles Mumps Rubella-Varicella vaccine in infants

        This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella... ...

        Research

        Participation in paediatric cancer studies: Timing and approach to recruitment

        In this sub-study, we aimed to investigate factors that may have influenced study participation and completeness of survey completion. ...

        Research

        Unique architectural features of mammalian mitochondrial protein synthesis

        Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has given rise to unique and idiosyncratic features of the mtDNA and its expression machinery that can be specific to different organisms. In animals, the mitochondrial protein synthesis machinery has acquired many new components and mechanisms over evolution. ...

        Research

        Illuminating mitochondrial translation through mouse models

        Mitochondria are hubs of metabolic activity with a major role in ATP conversion by oxidative phosphorylation (OXPHOS). The mammalian mitochondrial genome encodes 11 mRNAs encoding 13 OXPHOS proteins along with 2 rRNAs and 22 tRNAs, that facilitate their translation on mitoribosomes. ...

        News & Events

        Cystic fibrosis research a Eureka Prize finalist

        A world-leading cystic fibrosis research program, based at the Telethon Kids Institute, is a finalist in the 2015 Australian Museum Eureka Prizes. ...

        News & Events

        New test proves effective in more cancers

        Avantogen Limited (ACU:ASX) today announced that cancer researchers at Perth's Telethon Institute for Child Health Research (TICHR) and Avantogen Limited ...

        Research

        Exposomes and metabolic health through a physical activity lens: a narrative review

        In this narrative review, we provide an overview of the role of physical activity as part of differing exposomes (our combined non-genetic exposures from conception onwards) and environmental influences on metabolic health. We discuss 'beneficial' exposomes (green/natural outdoor spaces, sun exposure, healthy diets and features of built environments) that could synergise with physical activity to prevent metabolic dysfunction, particularly that related to lifestyle diseases of obesity, type 2 diabetes and metabolic syndrome. ...

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