The pattern of association between socioeconomic factors and health outcomes has primarily depicted better health for those who are higher in the social... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• November 2011

Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• March 2010

Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which therefore hold the potential to be used as a biomarker of this early life exposure. With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA methylation data and thereby generate a score for in utero cigarette smoke exposure. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

Our findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

Identify entrenched areas of asthma management and treatment in which progress has stalled and to challenge current principles ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Many important allergens are not covalently bound to lipid or carbohydrate, but have structures belonging to lipid, glycan and glycolipid-binding families. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

These findings suggest that this modified version of SLIT should be considered for retesting of mucosal-based immunotherapy for atopic asthma prevention. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• June 2013

This study contributes to our understanding of the genetic diversity of NMC, an important step towards finding therapeutic targets for a disease that is... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• November 2012