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        561-570 of 998 results for 'genetic'

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        Research

        Fetal growth and risk of childhood Acute Lymphoblastic Leukemia

        The relation between intrauterine growth and risk of childhood acute lymphoblastic leukemia was investigated in an Australian population-based case-control... ...

        Research

        Parental occupational exposure to engine exhausts and childhood brain tumors

        Increased risks were observed for maternal exposure to diesel exhaust any time before the child's birth and paternal exposure around the time of the child's... ...

        Research

        Parental occupational exposure to exhausts, solvents, glues and paints, and risk of childhood leukemia

        It is unknown whether parental occupational exposure to chemicals before during and after pregnancy increases the risk of acute lymphoblastic... ...

        Research

        Fetal growth and childhood acute lymphoblastic leukemia: Findings from the childhood leukemia international consortium

        The evidence that accelerated fetal growth is associated with a modest increased risk of childhood ALL is strong and consistent with known biological... ...

        Research

        Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

        Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs. ...

        Research

        Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation

        The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both individually and combinatorially. ...

        Early determinants of fractures in Rett syndrome

        Article title Downs J, Bebbington A, Woodhead H, Jacoby P, Jian L, Jefferson A, Leonard H. Early determinants of fractures in Rett syndrome. ...

        Research

        Development of new preclinical models of childhood leukaemia

        Sébastien Laurence Rishi Sury Malinge Cheung Kotecha SM LC RS PhD BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD Laboratory Head, Translational ...

        News & Events

        National network to significantly improve health outcomes for Indigenous Australians

        A new national network will be established to advance the benefits from Genomic Medicine for Aboriginal and Torres Strait Islander people living in Australia. ...

        News & Events

        Replication of rare aggressive brain cancer could pave the way for better treatments

        In an Australian-first, Telethon Kids Institute researchers have developed a new tool that could improve outcomes for children with a highly aggressive type of brain cancer. ...

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