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        Research

        A study of handling cytotoxic drugs and risk of birth defects in offspring of female veterinarians

        This paper examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female... ...

        Research

        Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive

        Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are often linked to respiratory infections. ...

        Research

        Updating estimates of Plasmodium knowlesi malaria risk in response to changing land use patterns across Southeast Asia

        Plasmodium knowlesi is a zoonotic parasite that causes malaria in humans. The pathogen has a natural host reservoir in certain macaque species and is transmitted to humans via mosquitoes of the Anopheles Leucosphyrus Group. The risk of human P. knowlesi infection varies across Southeast Asia and is dependent upon environmental factors.  ...

        Research

        Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae

        The aim of this study was to identify features of innate, cell-mediated and humoral immunity that may increase susceptibility to respiratory infections in... ...

        Research

        House dust mite allergens in asthma and allergy

        IgE antibodies in house dust mite (HDM) allergy follow a predictable pattern. Half are directed against two dominant allergens and the remainder largely against ...

        Research

        Individual variation in vaccine immune response can produce bimodal distributions of protection

        The ability for vaccines to protect against infectious diseases varies among individuals, but computational models employed to inform policy typically do not account for this variation. Here we examine this issue: we implement a model of vaccine efficacy developed in the context of SARS-CoV-2 in order to evaluate the general implications of modelling correlates of protection on the individual level. ...

        Research

        Host Immune Response to Scabies

        Scabies infection is associated with heightened total IgE immunoglobulin and IgE antibodies to scabies antigens, with both being extremely high for crusted scabies patients. The IgE antibodies cross-react with house dust mite allergens with high reactivity found to the minor allergen arginine kinase. ...

        Research

        Quantitation of IgE Binding to the Chitinase and Chitinase-Like House Dust Mite Allergens

        The prevalence of IgE binding to the group 15 and 18 house dust mite (HDM) allergens of the Dermatophagoides species... ...

        Research

        Toll-like receptor 2 ligands inhibit Th2 responses to mite allergen

        There is intense interest in the interaction between microbial compounds and allergy. ...

        Research

        IgE and IgG binding patterns and T-cell recognition of fel d 1 and Non-Fel d 1 cat allergens

        To compare IgE and IgG antibody binding and T-cell recognition of the major cat allergen Fel d 1 with other cat proteins with known IgE binding properties. ...

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