For decades, the research community has called for participant information sheets/consent forms (PICFs) to be improved. Recommendations include simplifying content, reducing length, presenting information in layers and using multimedia. However, there are relatively few studies that have evaluated health consumers' (patients/carers) perspectives on the type and organisation of information, and the level of detail to be included in a PICF to optimise an informed decision to enter a trial. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Implementation of molecular testing could improve antibiotic use in this high-burden setting ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

Households are known to be high-risk locations for the transmission of communicable diseases. Numerous modelling studies have demonstrated the important role of households in sustaining both communicable diseases outbreaks and endemic transmission, and as the focus for control efforts. However, these studies typically assume that households are associated with a single dwelling and have static membership. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

The use of adjunctive antibiotics directed against exotoxin production in Staphylococcus aureus bacteremia (SAB) is widespread, and is recommended in many guidelines, but there is limited evidence underpinning this. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

Acute rheumatic fever (ARF) is an abnormal immune reaction following Streptococcus pyogenes (Strep A) infection of the throat, and likely the skin. Primary prevention is the prompt and appropriate antibiotic treatment of Strep A infection, and it can reduce the risk of developing ARF and subsequent rheumatic heart disease. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), sparking a global pandemic, has driven an imperative to quickly design and conduct treatment studies. We strongly propose a national, coordinated approach for randomised controlled trials (RCTs) for coronavirus disease 2019 (COVID-19), future pandemics and inter-pandemic periods in Australia. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

The burden and consequences of skin infections for remote living indigenous people are high ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Rates of antimicrobial resistance (AMR) for some pathogens in Australia are considerably higher in rural and remote compared to urban regions. The inaugural Hot North Antimicrobial Academy was a 9-month educational programme aimed to build workforce knowledge and capacity in antimicrobial use, audit, stewardship, surveillance and drug resistance in remote primary health care.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• March 2024