Asthma is among the commonest noncommunicable diseases of childhood and often occurs with other atopic comorbidities. A previous case-control study found evidence that compared to children who received acellular pertussis (aP) vaccines in early infancy, children who received one or more doses of whole-cell pertussis (wP) vaccine had lower risk of developing IgE-mediated food allergy. We hypothesized that wP vaccination in early infancy might protect against atopic asthma in childhood.  ...

• 1. Telethon Kids Institute
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• 2023
• October 2023

There is substantial interest in studying lung function in infants, to better understand the early life origins of chronic lung diseases such as asthma. ...

• 1. Telethon Kids Institute
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• 2015
• January 2015

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. ...

• 1. Telethon Kids Institute
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• 2023
• March 2023

This is a protocol for a Cochrane Review (intervention). The objectives were to assess the efficacy and safety of whole‐cell pertussis (wP) vaccinations in comparison to acellular pertussis (aP) vaccinations in early infancy for the prevention of atopic diseases in children. ...

• 1. Telethon Kids Institute
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• 2020
• July 2020

The burden of bronchiectasis is disproportionately high in Aboriginal adults, with early mortality. Bronchiectasis precursors, that is, protracted bacterial bronchitis and chronic suppurative lung disease, often commence in early childhood. ...

• 1. Telethon Kids Institute
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• 2022
• September 2022

Elizabeth Graham Smith Hall ES GL PhD, MSc, BSc BAppSci PhD CRFS FANZSRS FThorSoc FERS Program Manager Honorary Research Associate 08 6319 1178 ...

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The Opportunity The diverse activities of the newly established Telethon Kids Respiratory Research Centre will be coordinated by the Program Manager ...

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Streptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae is associated with otitis media ...

• 1. Telethon Kids Institute
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• 2011
• June 2011

One in eight children have asthma, a chronic disease of the airways in the lungs. It results in shortness of breath, chest tightness, wheezing and coughing. ...

• 1. Telethon Kids Institute
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These findings suggest the utility of specific FOT outcomes is dependent on the respiratory disease being assessed ...

• 1. Telethon Kids Institute
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• 2019
• June 2019