Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions. ...

• 1. Telethon Kids Institute
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• 2021
• March 2021

disease-deconvolution" identified associations between the parasite-brain interactions and epilepsy, movement disorders, Alzheimer's disease, and cancer. ...

• 1. Telethon Kids Institute
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• 2017
• September 2017

There is a 30% higher case fatality rate from cancer in psychiatric patients even though their incidence of cancer is no greater than in the general population. ...

• 1. Telethon Kids Institute
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• 2013
• February 2013

The goal of a clinical quality registry is to deliver immediate gains in survival and quality of life by delivering timely feedback to practitioners, thereby ensuring every patient receives the best existing treatment. We are developing an Australian Brain Cancer Registry (ABCR) to identify, describe, and measure the impact of the variation and gaps in brain cancer care from the time of diagnosis to the end of life. ...

• 1. Telethon Kids Institute
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• 2021
• August 2021

Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the role of individual subtypes remains unclear. Here we systematically compared the capacity of distinct type I IFN subtypes to enhance T cell responses to a whole-cell vaccination strategy in a pre-clinical murine model. ...

• 1. Telethon Kids Institute
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• 2021
• September 2021

Given that the transcriptional regulatory activity of estrogen receptor (ER) is modulated by its biochemical cofactors, genetic variation within the ER... ...

• 1. Telethon Kids Institute
• Our research
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• 2012
• August 2012

Cancer research is being reimagined after a collaboration between the Telethon Kids Institute, the Peter Doherty Institute for Infection and Immunity. ...

• 1. Telethon Kids Institute
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• 2019
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The Opportunity The Telethon Kids Institutes Cancer Immunology group is focused on harnessing the power of the immune system to eradicate primary and ...

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Evidence suggests the involvement of the microbiota, including oral, intra-tumoral and gut, in pancreatic cancer progression and response to therapy. The gut microbiota modulates the bile acid pool and is associated with maintaining host physiology. Studies have shown that the bile acid/gut microbiota axis is dysregulated in pancreatic cancer. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Elliot Parish never climbed a mountain. Never saw the Great Wall of China or myriad other wonders of the world. Never got the chance to grow up.  ...

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• 2015