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        Research

        Factors influencing the assessment of lung function in mice with influenza-induced lung disease

        The constant-phase model (CPM) is commonly fit to respiratory system input impedance (Z rs) to estimate lung mechanics. ...

        Research

        Gateways to the FANTOM5 promoter level mammalian expression atlas

        The FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines and tissues using CAGE. ...

        Research

        ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption

        Osteoporosis is a chronic skeletal condition characterized by low bone mass and deteriorated microarchitecture of bone tissue and puts tens of millions of people at high risk of fractures. New therapeutic agents like i-bodies, a class of next-generation single-domain antibodies, are needed to overcome some limitations of conventional treatments. ...

        Research

        Intrauterine growth restriction affects diaphragm function in adult female and male mice

        Sex and intrauterine growth restriction independently affect diaphragm contraction in adult mice without changes in structure ...

        Research

        Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen

        The aims of this study were to clone the cDNA of Der f 14 corresponding to M-177 and to elucidate the allergenic capacities of the Der f 14-N. ...

        Research

        Physiological and inflammatory responses in an anthropomorphically relevant model of acute diesel exhaust particle exposure are sex and dose-dependent

        Diesel exhaust particles (DEP) are an important contributor to suspended particulate matter (PM) in urban areas. While epidemiological evidence exists for a... ...

        Research Assistant Cancer Immunology

        The purpose of this role is to evaluate cancer neoantigens in oncogenic mouse models, in order to develop novel peptide vaccines. The Telethon Kids ...

        Research

        Coexpression of nuclear receptors and histone methylation modifying genes in the testis: Implications for endocrine disruptor modes of action

        We hypothesised that histone methylation may be a component of the epigenome that is susceptible to perturbation. ...

        News & Events

        Every Friday: Child Health Research Seminars 2014

        Dr Howlett completed her PhD studies in 2009 at the MCRI in Melbourne, where she worked on gastric cancer cell signaling...a ...

        Research

        Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation early development

        The predominant occurrence of extragonadal teratomas/teratocarcinomas in human neonates suggests that pluripotent cells are tumour-forming even during... ...

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