Acute lymphoblastic leukemia (ALL) in infants younger than 1 year of age is an aggressive, high-risk subtype of childhood ALL. Infant ALL with KMT2A-r is characteristically poorly responsive to chemotherapy and hematopoietic stem cell transplantation. New strategies, such as molecularly targeted therapies and immunotherapies, are in development and show promise in preclinical models and early phase studies. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

The COVID-19 pandemic has overwhelmed health systems in both developed and developing nations alike. Africa has one of the weakest health systems globally, but there is limited evidence on how the region is prepared for, impacted by and responded to the pandemic. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

Interventions to address alcohol use during pregnancy need to target underlying determinants of the behaviour. Using the theory of planned behaviour as a theoretical framework, the aim of this study was to identify behavioural, normative and control beliefs regarding alcohol use during pregnancy among a sample of women. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

To establish the burden of respiratory illness in cerebral palsy (CP) on the Western Australian health care system by quantifying the costs of respiratory hospitalizations in children with CP, compared with non-respiratory hospitalizations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Reliable and detailed data on the prevalence of tuberculosis (TB) with sub-national estimates are scarce in Ethiopia. We address this knowledge gap by spatially predicting the national, sub-national and local prevalence of TB, and identifying drivers of TB prevalence across the country. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants is an aggressive disease with 3-year event-free survival below 40%. Most relapses occur during treatment, with two thirds occurring within 1 year and 90% within 2 years after diagnosis. Outcomes have not improved in recent decades despite intensification of chemotherapy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

There is mounting concern over the potential harms associated with ultra-processed foods, including poor mental health and antisocial behavior. Cutting-edge research provides an enhanced understanding of biophysiological mechanisms, including microbiome pathways, and invites a historical reexamination of earlier work that investigated the relationship between nutrition and criminal behavior. Here, in this perspective article, we explore how this emergent research casts new light and greater significance on previous key observations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Multidrug-resistant tuberculosis (MDR-TB) is a global health threat associated with high morbidity and mortality rates. Diagnosis and treatment delays are associated with poor treatment outcomes in patients with MDR-TB. However, the risk factors associated with these delays are not robustly investigated, particularly in high TB burden countries such as China. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

This manuscript will give a brief overview of clinical trial design including the strengths and limitations of various approaches ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

This review describes the evolution of bronchopulmonary dysplasia definitions, evaluates the benefits and limitations of each approach ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019