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        Research

        Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

        Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs. ...

        Early determinants of fractures in Rett syndrome

        Article title Downs J, Bebbington A, Woodhead H, Jacoby P, Jian L, Jefferson A, Leonard H. Early determinants of fractures in Rett syndrome. ...

        Research

        DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children

        Allergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis. ...

        Research

        The epigenetic origin of alcohol-induced disorders: a cross-species study

        Alexander David Martyn Larcombe Martino Symons A DM MS BScEnv (Hons) PhD BSc PhD B.A. (Hons) PhD. Team Leader, Respiratory Environmental Health Head, ...

        Research

        Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthma

        Bacterial colonisation of the airways is associated with increased risk of childhood asthma ...

        Research

        Measuring use and cost of health sector and related care in a population of girls and young women with Rett syndrome

        This study measured use and cost of health sector and related services in Rett syndrome and effects of socio-demographic, clinical severity and genetic... ...

        Research

        Functional differences in airway dendritic cells determine susceptibility to IgE-sensitization

        Respiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma. ...

        Research

        Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infection

        Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection ...

        Innovation and commercialisation

        We identify, develop and commercialise the technologies and innovations developed by our scientists and clinicians. ...

        About Rett syndrome

        What is Rett syndrome? There are 4 main criteria considered when diagnosing Rett syndrome Main health issues Rett syndrome is one of the 8,000 rare ...

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